Ablation of CCDC8 provides cardioprotection against cardiomyocyte apoptosis via TNF signaling pathway in myocardial ischemia reperfusion injury
This study identifies CCDC8 as a key mediator of cardiomyocyte apoptosis via the TNF signaling pathway in myocardial I/R injury. These findings suggest that targeting CCDC8 could be a potential therapeutic strategy for mitigating cardiac dysfunction in myocardial I/R injury.
Authors
- Zexiong Li (ORCID: https://orcid.org/0000-0002-5515-3368)
- Shaoru Jiang
- Junmeng Zheng (ORCID: https://orcid.org/0000-0002-4243-8209)
- Weipeng Huang
- Jun Lin (ORCID: https://orcid.org/0000-0001-5583-895X)
- Mingwei Xu (ORCID: https://orcid.org/0009-0003-6405-6740)
- Junbing He
- Jungang Huang
Institutions
- Sun Yat-sen University (CN)
- Wenzhou Medical University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Yang Hospital (KR)
- Dongyang People's Hospital (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1016/j.lfs.2024.123151
- Citations
- 3
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 1.27
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Basic and Applied Basic Research Foundation of Guangdong Province