Novel ryanodine receptor 1 (RYR1) missense gene variants in two pet dogs with fatal malignant hyperthermia identified by next-generation sequencing
Like humans, MH susceptibility in dogs is associated with different rare variants located in pathogenic hotspots in the RYR-1 gene. Next-generation sequencing is a useful tool to assist in the definitive diagnosis of MH in dogs.
Authors
- Holly L. Neibergs (ORCID: https://orcid.org/0000-0001-8121-3072)
- Tania Perez Jimenez (ORCID: https://orcid.org/0000-0002-5867-5276)
- Michael H. Court (ORCID: https://orcid.org/0000-0002-2122-9977)
- Christopher C. Rider (ORCID: https://orcid.org/0000-0002-3312-0063)
- Ousseini Issaka Salia (ORCID: https://orcid.org/0000-0002-1176-0473)
- Erich Spoor (ORCID: https://orcid.org/0000-0001-7472-1124)
- Zhaohui Zhu (ORCID: https://orcid.org/0000-0002-3146-6714)
Institutions
- Lynn University (US)
- Rocky Mountain Multiple Sclerosis Clinic (US)
- Washington State University (US)
Publication Details
- Journal
- Veterinary Anaesthesia and Analgesia
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1016/j.vaa.2024.10.131
- Citations
- 2
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.10
Funders
- Washington State University