Novel Thiourea Ligands—Synthesis, Characterization and Preliminary Study on Their Coordination Abilities

Two series of polydentate <i>N</i>,<i>O</i>,<i>S</i>-ligands containing thiourea fragments attached to a <i>p</i>-cresol scaffold, unsymmetrical mono-acylated bis-amines and symmetrical bis-thioureas, are obtained by common experiments. It is observed that the reaction output is strongly dependent on both bis-amine and thiocarbamic chloride substituents. The products are characterized by 1D and 2D NMR spectra in solution and by single crystal XRD. A preliminary study on the coordination abilities of selected products is performed by ITC at around neutral media.