Hypoxia-Associated Gene Signatures Are Not Prognostic in High-Risk Localized Prostate Cancers Undergoing Androgen Deprivation Therapy With Radiation Therapy
Hypoxia and radiosensitivity biomarkers were not prognostic in patients with high-risk PCa treated with ADT plus radiation therapy. We speculate that the lack of prognostic capability could be caused by the variable hypoxia-modifying effects of the ADT that these high-risk patients received before and during definitive treatment with radiation therapy. A deeper understanding of biomarker construction, performance, and inter-cohort transferability in relation to patient characteristics, sample handling, and treatment modalities is required before hypoxia biomarkers can be recommended for routine clinical use in the pretreatment setting.
Authors
- Alexander J. Vickers (ORCID: https://orcid.org/0000-0001-9502-1450)
- Peter Hoskin (ORCID: https://orcid.org/0000-0001-8323-9567)
- Robert G. Bristow (ORCID: https://orcid.org/0000-0002-8553-9544)
- Rob Rodrigues Pereira (ORCID: https://orcid.org/0000-0003-0212-9011)
- B. Bibby (ORCID: https://orcid.org/0000-0003-0181-7728)
- Elisabet Moré (ORCID: https://orcid.org/0000-0002-8368-1256)
- Ananya Choudhury (ORCID: https://orcid.org/0000-0002-3561-6580)
- Helen Denley
- Daniel Spratt (ORCID: https://orcid.org/0000-0002-8909-0510)
- Hitesh Mistry (ORCID: https://orcid.org/0000-0002-9683-1903)
- Y. Tsang (ORCID: https://orcid.org/0000-0002-5369-3299)
- Niluja Thiruthaneeswaran (ORCID: https://orcid.org/0000-0002-0253-0895)
- Timothy Smith (ORCID: https://orcid.org/0000-0002-3945-630X)
- Catharine West (ORCID: https://orcid.org/0000-0002-0839-3449)
- Mi Heon Ryu (ORCID: https://orcid.org/0000-0003-1283-9762)
- Ann Henry (ORCID: https://orcid.org/0000-0002-5379-6618)
- James Wylie
- Alex Hakansson
- Mark Reardon
- Kimberley J. Reeves
Institutions
- The University of Sydney (AU)
- University of Leeds (GB)
- Bangor University (GB)
- Manchester Academic Health Science Centre (GB)
- Royal Shrewsbury Hospital (GB)
- Princess Margaret Cancer Centre (CA)
- University of Manchester (GB)
- University Hospitals Seidman Cancer Center (US)
- Veracyte (United States) (US)
- The Christie Hospital (GB)
- The Christie NHS Foundation Trust (GB)
- Shrewsbury and Telford Hospital NHS Trust (GB)
Publication Details
- Journal
- International Journal of Radiation Oncology*Biology*Physics
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1016/j.ijrobp.2024.10.002
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Pfizer
- Movember Foundation
- Veracyte
- Cancer Research UK
- National Institute for Health and Care Research
- Prostate Cancer UK
- Cancer Research UK Manchester Centre
- Manchester Biomedical Research Centre