Polygenic risk scores stratify breast cancer risk among women with benign breast disease
Breast cancer risks are elevated among women with benign breast disease and increase progressively with polygenic risk score, suggesting that optimal combinations of these factors may improve risk stratification.
Authors
- Mark E. Sherman (ORCID: https://orcid.org/0000-0002-9222-8808)
- Amy C. Degnim (ORCID: https://orcid.org/0000-0002-2303-4946)
- Bryan M. McCauley (ORCID: https://orcid.org/0000-0003-4014-2663)
- Fergus J. Couch (ORCID: https://orcid.org/0000-0001-9417-9985)
- Jenny Chang‐Claude (ORCID: https://orcid.org/0000-0001-8919-1971)
- Robert A. Vierkant (ORCID: https://orcid.org/0000-0001-6242-5221)
- Stacey J. Winham (ORCID: https://orcid.org/0000-0002-8492-9102)
- Thérèse Truong (ORCID: https://orcid.org/0000-0002-2943-6786)
- Celine M Vachon
- Pascal Guénel (ORCID: https://orcid.org/0000-0002-8359-518X)
- Alison M. Dunning (ORCID: https://orcid.org/0000-0001-6651-7166)
- Thomas U. Ahearn (ORCID: https://orcid.org/0000-0003-0771-7752)
- Kyriaki Michailidou (ORCID: https://orcid.org/0000-0001-7065-1237)
- Derek C. Radisky (ORCID: https://orcid.org/0000-0002-1962-8784)
- Nasim Mavaddat (ORCID: https://orcid.org/0000-0003-0307-055X)
- Rachel A. Murphy (ORCID: https://orcid.org/0000-0003-4383-5641)
- Joe Dennis
- Sandhya Pruthi (ORCID: https://orcid.org/0000-0002-2235-4542)
- Melissa A. Troester (ORCID: https://orcid.org/0000-0001-9506-6624)
- Montserrat García‐Closas (ORCID: https://orcid.org/0000-0003-1033-2650)
- Mia M. Gaudet (ORCID: https://orcid.org/0000-0002-6429-4007)
- Christopher G. Scott (ORCID: https://orcid.org/0000-0003-1340-0647)
- Kristan J. Aronson (ORCID: https://orcid.org/0000-0002-7865-7243)
- Stephen J. Chanock (ORCID: https://orcid.org/0000-0002-2324-3393)
- Sarah E. Schrup
- Nadia Obi
- Douglas F. Easton
- Paul D.P. Pharoah
- Qin Wang
- Xiaohong Yang
- Manjeet K. Bolla (ORCID: https://orcid.org/0000-0002-4351-9326)
Institutions
- University of North Carolina at Chapel Hill (US)
- National Institutes of Health (US)
- Mayo Clinic (US)
- University of British Columbia (CA)
- Inserm (FR)
- Universität Hamburg (DE)
- German Cancer Research Center (DE)
- Queen's University (CA)
- Heidelberg University (DE)
- University of Cambridge (GB)
- Jacksonville College (US)
- Cancer Research UK Cambridge Center (GB)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- University Medical Center Hamburg-Eppendorf (DE)
- National Cancer Institute (UA)
- Mayo Clinic Health System (US)
- Mayo Clinic in Arizona (US)
- University Cancer Center Hamburg (DE)
- National Cancer Institute (US)
- Mayo Clinic in Florida (US)
- Department of Health and Human Services (US)
- UNC Lineberger Comprehensive Cancer Center
- Division of Cancer Epidemiology and Genetics
- Cyprus Institute of Neurology and Genetics (CY)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1093/jnci/djae255
- Citations
- 3
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.65
Funders
- Genome Canada
- Government of Canada
- Cancer Research UK
- National Institute for Health and Care Research
- Department of Health and Social Care
- European Commission
- National Institutes of Health
- Canadian Institutes of Health Research
- National Cancer Institute