Employing single-cell RNA sequencing coupled with an array of bioinformatics approaches to ascertain the shared genetic characteristics between osteoporosis and obesity
Our study underscores the pivotal role of <i>TLR2</i> in connecting OP and OB. It highlights the influence of <i>TLR2</i> in macrophages, driving both diseases through a pro-inflammatory mechanism. These insights propose <i>TLR2</i> as a potential dual therapeutic target for treating OP and OB.
Authors
- Dian Liu (ORCID: https://orcid.org/0009-0007-2185-1479)
- Yue Zhu (ORCID: https://orcid.org/0000-0002-0126-496X)
- Fangming Cao (ORCID: https://orcid.org/0000-0003-3472-9564)
- Hao Li (ORCID: https://orcid.org/0000-0003-0513-0771)
- Dan Liu (ORCID: https://orcid.org/0000-0001-8906-6361)
- Lin Tao (ORCID: https://orcid.org/0000-0002-1702-9833)
Institutions
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Bone and Joint Research
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1302/2046-3758.1310.bjr-2023-0366.r1
- Citations
- 5
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.17