Unique transcriptomic profile of peripheral blood monocytes in rheumatoid arthritis-associated interstitial lung disease
Circulating monocytes in RA-ILD patients demonstrate unique gene expression profiles, with innate immune gene features more aligned with IPF as opposed to RA in the absence of clinical lung disease, and with fibrosis gene expression that was distinct from RA and IPF. These studies are important for understanding disease pathogenesis and may provide information for future therapeutic targets in RA-ILD.
Authors
- Bridget Kramer
- Rhonda Walenz
- Joel Van De Graaff (ORCID: https://orcid.org/0000-0002-3841-4765)
- Sara May
- Jill A. Poole (ORCID: https://orcid.org/0000-0002-6236-2563)
- Debra J. Romberger (ORCID: https://orcid.org/0000-0003-3037-564X)
- Daniel Hershberger (ORCID: https://orcid.org/0009-0008-7737-8171)
- Geoffrey M. Thiele (ORCID: https://orcid.org/0000-0001-5688-8596)
- Kristina L. Bailey (ORCID: https://orcid.org/0000-0003-2990-9042)
- Aaron Schwab (ORCID: https://orcid.org/0000-0003-1142-7790)
- Ted R. Mikuls (ORCID: https://orcid.org/0000-0002-0897-2272)
- Bryant R. England (ORCID: https://orcid.org/0000-0002-9649-3588)
- Michael J. Duryee (ORCID: https://orcid.org/0000-0001-9104-2238)
- Amy Nelson
- Angela Gleason
Institutions
- Nebraska Medical Center (US)
- VA Nebraska Western Iowa Health Care System (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1093/rheumatology/keae572
- Citations
- 8
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 3.35
Funders
- U.S. Department of Defense
- U.S. Department of Veterans Affairs
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Rheumatology Research Foundation
- University of Nebraska Medical Center
- Regeneron Pharmaceuticals
- Celldex Therapeutics
- Horizon Therapeutics
- National Institutes of Health
- National Cancer Institute
- National Institute of General Medical Sciences
- National Institute for Occupational Safety and Health