Lewis Acid‐Promoted C−H Chalcogenation of Arenes and Heteroarenes
Abstract An efficient catalytic system employing TMS•OTf for the regioselective thiolation of electron‐rich arenes with sulfonyl hydrazides has been developed. The reaction occurs in a solvent mixture of dichloroethane and trifluoroethanol under mild conditions, with the addition of water. This method furnishes a range of para ‐thio‐substituted arenes and 3‐sulfenyl‐indoles in good to excellent yields, marking a significant advancement in organic synthesis.
Authors
- Rahul Vishwakarma (ORCID: https://orcid.org/0000-0003-3197-4847)
- Chinmoy Kumar Hazra (ORCID: https://orcid.org/0000-0001-5968-5305)
- Pragya Sharma (ORCID: https://orcid.org/0000-0001-6405-7872)
Institutions
- Indian Institute of Technology Delhi (IN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1002/ejoc.202400894
- Citations
- 4
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- Ministry of Education, India
- Indian Institute of Technology Delhi
- Science and Engineering Research Board