S100A8 knockdown activates the PI3K/AKT signaling pathway to inhibit microglial autophagy and improve cognitive impairment mediated by chronic sleep deprivation
The S100A8/PI3K/AKT axis plays a crucial role in chronic sleep deprivation-mediated autophagy and apoptosis in microglia.
Authors
- Fuzhou Hua (ORCID: https://orcid.org/0000-0002-6718-6490)
- Lieliang Zhang (ORCID: https://orcid.org/0009-0005-5700-6096)
- Xifeng Wang (ORCID: https://orcid.org/0000-0002-4982-8947)
- Hong‐Jian Zhu (ORCID: https://orcid.org/0000-0002-1478-995X)
- Binwu Ying (ORCID: https://orcid.org/0000-0001-8077-3908)
- Gen Wei (ORCID: https://orcid.org/0000-0002-4778-4901)
- Weidong Liang (ORCID: https://orcid.org/0000-0002-8290-3216)
- Hailin Liu (ORCID: https://orcid.org/0000-0003-2807-3781)
- Yue Lin
- Yanhong Xiong (ORCID: https://orcid.org/0009-0002-9416-039X)
- Pengcheng Yi (ORCID: https://orcid.org/0009-0008-3719-1230)
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- First Affiliated Hospital of Gannan Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1016/j.intimp.2024.113375
- Citations
- 11
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- JiangXi Province Human Resources and Social Security Department
- National Natural Science Foundation of China
- Jiangsu Province Key Laboratory of Anesthesiology
- Qinghai Provincial Key Laboratory of Tibetan Medicine Research