Distinct roles for the domains of the mitochondrial aspartate/glutamate carrier citrin in organellar localization and substrate transport
Our work introduces a new role for the N-terminal domain of citrin and demonstrates that dysfunction of the different domains contributes to distinct pathogenic mechanisms in citrin deficiency.
Authors
- Sotiria Tavoulari (ORCID: https://orcid.org/0000-0002-4263-8905)
- Shane M. Palmer (ORCID: https://orcid.org/0000-0002-6457-0761)
- John E. Walker (ORCID: https://orcid.org/0000-0001-7929-2162)
- Denis Lacabanne (ORCID: https://orcid.org/0000-0002-8911-3794)
- Gonçalo C. Pereira (ORCID: https://orcid.org/0000-0001-9638-0615)
- Chancievan Thangaratnarajah (ORCID: https://orcid.org/0000-0002-0279-6642)
- Julien Prudent (ORCID: https://orcid.org/0000-0003-3821-6088)
- Edmund R.S. Kunji (ORCID: https://orcid.org/0000-0002-0610-4500)
- Martin King (ORCID: https://orcid.org/0000-0001-6030-5154)
- Lisa Tilokani (ORCID: https://orcid.org/0000-0003-1228-6985)
- Jiuya He (ORCID: https://orcid.org/0000-0002-8602-1202)
- Suvagata Roy Chowdhury (ORCID: https://orcid.org/0000-0001-6127-5276)
Institutions
- MRC Mitochondrial Biology Unit (GB)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1016/j.molmet.2024.102047
- Citations
- 10
- Primary Topic
- Amino Acid Enzymes and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.95
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Citrin Foundation
- Medical Research Council