Comprehensive atlas of mitochondrial distribution and dynamics during oocyte maturation in mouse models
Our findings reveal that mitochondria in mouse oocytes are highly dynamic, undergoing significant reorganizations during oocyte maturation. We for the first time provided comprehensive mitochondrial distribution profiles in mouse oocytes at the GV, MI and MII stages. These mitochondrial distribution profiles were further quantitatively evaluated. Our methods provide an objective and standardized approach for evaluating alterations in mitochondrial dynamics, which can be used as biomarkers to monitor oocyte conditions during maturation.
Authors
- Jian Zhao (ORCID: https://orcid.org/0000-0001-5659-730X)
- Kenny A. Rodriguez‐Wallberg (ORCID: https://orcid.org/0000-0003-4378-6181)
- Xia Hao (ORCID: https://orcid.org/0009-0006-6791-9603)
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- Wallenberg Wood Science Center (SE)
Publication Details
- Journal
- Biomarker Research
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1186/s40364-024-00672-z
- Citations
- 16
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 8.69
Funders
- National Natural Science Foundation of China
- Cancerfonden
- Karolinska Institutet
- Stockholms Läns Landsting
- Vetenskapsrådet
- Barncancerfonden