Adverse reaction of specific acute kidney injury caused by atorvastatin: an actual study based on the database of the US FDA adverse event reporting system

In the general population, evidence for a positive AKI signal was insufficient. However, subgroup analysis showed risk in males and older individuals in AMI and IS populations, while younger age groups in T2DM showed positive signals. In the HLD population, evidence was insufficient across genders and ages. Atorvastatin is generally safe, but clinical vigilance for AKI is needed in T2DM, AMI, and IS populations, especially in those 65 and older.

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Publication Details

Journal
Expert Opinion on Drug Safety
Published
2024-10-16
DOI
https://doi.org/10.1080/14740338.2024.2416919
Primary Topic
Pharmacovigilance and Adverse Drug Reactions
Type
article
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article

Adverse reaction of specific acute kidney injury caused by atorvastatin: an actual study based on the database of the US FDA adverse event reporting system

Manting Liu, Jiyuan Zheng, Caishan Fang, Jiazhen Jiang et al.
1 links
Expert Opinion on Drug Safety
Pharmacovigilance and Adverse Drug Reactions
article

Adverse reaction of specific acute kidney injury caused by atorvastatin: an actual study based on the database of the US FDA adverse event reporting system

Manting Liu, Jiyuan Zheng, Caishan Fang, Jiazhen Jiang, Hanlin Dong, Dongqiang Luo, Zhenye Chen
article en

Abstract

In the general population, evidence for a positive AKI signal was insufficient. However, subgroup analysis showed risk in males and older individuals in AMI and IS populations, while younger age groups in T2DM showed positive signals. In the HLD population, evidence was insufficient across genders and ages. Atorvastatin is generally safe, but clinical vigilance for AKI is needed in T2DM, AMI, and IS populations, especially in those 65 and older.

Expert Opinion on Drug SafetyVol. 25(2)
Guangzhou University of Chinese Medicine (CN), General Hospital of Guangzhou Military Command (CN), Chengdu University of Traditional Chinese Medicine (CN), Southern Medical University (CN)
Good health and well-being
Openalex Percentile: Top 82%
Pharmacovigilance and Adverse Drug Reactions
DOISourceOpenAlex
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Adverse reaction of specific acute kidney injury caused by atorvastatin: an actual study based on the database of the US FDA adverse event reporting system — Manting Liu, Jiyuan Zheng, et al. · Expert Opinion on Drug Safety (2024) | TGRS Research Map | TGRS