Multi-Characteristic Opsin Therapy to Functionalize Retina, Attenuate Retinal Degeneration, and Restore Vision in Mouse Models of Retinitis Pigmentosa
As reported here, optogenetic treatment of the inner retina attenuates further retinal degeneration in addition to photosensitizing higher order neurons, and this disease-modifying aspect should be evaluated in optogenetic clinical trials.
Authors
- Najam A. Sharif (ORCID: https://orcid.org/0000-0002-4432-730X)
- Darryl Narcisse
- Subrata Batabyal (ORCID: https://orcid.org/0000-0002-0859-6641)
- Samarendra Mohanty (ORCID: https://orcid.org/0000-0002-6533-383X)
- Sang Hoon Kim (ORCID: https://orcid.org/0000-0002-4078-6269)
- Adnan Dibas
- Kissaou Tchedre
- Michael Carlson
Institutions
- Scope Group (United States) (US)
Publication Details
- Journal
- Translational Vision Science & Technology
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1167/tvst.13.10.25
- Citations
- 10
- Primary Topic
- Photoreceptor and optogenetics research
- Type
- article
- Field-Weighted Citation Impact
- 2.68
Funders
- National Institutes of Health