Extracellular Vesicles Contribute to Oxidized LDL-Induced Stromal Cell Proliferation in Benign Prostatic Hyperplasia
The findings suggest that dyslipidemia drives prostatic stromal cell proliferation and EV secretion, contributing to BPH progression. Metformin demonstrates potential as a therapeutic agent to mitigate these effects, offering insight into novel strategies for BPH management. This study highlights the complex interaction between dyslipidemia, cell proliferation, and extracellular communication in the context of BPH pathogenesis.
Authors
- Franco F. Roldán Gallardo (ORCID: https://orcid.org/0000-0003-0692-8873)
- Amado A. Quintar (ORCID: https://orcid.org/0000-0002-9283-8219)
- Manuel López Seoane
- Gabriela Berg (ORCID: https://orcid.org/0000-0002-5787-8960)
- Jael D. Herzfeld (ORCID: https://orcid.org/0000-0002-1465-7084)
- Vanina G. Da Ros (ORCID: https://orcid.org/0000-0003-2367-0042)
- Daniel E. Martínez Piñerez
- Kevin F. Reinarz Torrado
- Cristina A. Maldonado
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad Nacional de Córdoba (AR)
- Universidad de Buenos Aires (AR)
- Instituto de Investigaciones en Ciencias de la Salud (AR)
- Fundacion Allende (AR)
- Experimental Medicine and Biology Institute (AR)
Publication Details
- Journal
- Biology
- Published
- 2024-10-16
- DOI
- https://doi.org/10.3390/biology13100827
- Citations
- 2
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Universidad Nacional de Córdoba
- Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación