A First-Passage Model of Intravitreal Drug Delivery and Residence Time—Influence of Ocular Geometry, Individual Variability, and Injection Location
The modeling results suggest that experimental variability in ocular half-life is partially attributed to anatomical differences and injection site location. Simulations further suggest a potential role of the posterior pathway permeability in determining species differences in ocular pharmacokinetics.
Authors
- Antonello Caruso (ORCID: https://orcid.org/0000-0001-5832-3636)
- Philip K. Maini (ORCID: https://orcid.org/0000-0002-0146-9164)
- Eamonn A. Gaffney (ORCID: https://orcid.org/0000-0002-6888-4362)
- Michael Gertz (ORCID: https://orcid.org/0000-0003-4530-6110)
- Jessica R. Crawshaw (ORCID: https://orcid.org/0000-0003-0797-1144)
- Patricia Lamirande (ORCID: https://orcid.org/0000-0001-6585-4734)
Institutions
- Roche (Switzerland) (CH)
- Queensland University of Technology (AU)
- University of Oxford (GB)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1167/iovs.65.12.21
- Citations
- 9
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.85
Funders
- AstraZeneca
- Natural Sciences and Engineering Research Council of Canada
- Engineering and Physical Sciences Research Council