Talauromides A–G, Nitrogen-Containing Heptacyclic Oligophenalenone Dimers from the Soil Fungus <i>Talaromyces stipitatus</i> BMC-16
Seven new nitrogen-containing heptacyclic oligophenalenone dimers, talauromides A-G (<b>1</b>-<b>7</b>), together with known compounds bacillisporins A and B (<b>8</b> and <b>9</b>), talaromycesones C and B (<b>10</b> and <b>11</b>), duclauxin (<b>12</b>) and lamellicolic anhydride (<b>13</b>), were isolated from the soil derived-fungus <i>Talaromyces stipitatus</i> BMC-16. Their chemical structures were determined based on spectroscopic analysis data. The absolute configurations were elucidated by chemical approaches and the comparison of CD spectra with related compounds. Compounds <b>3</b>, <b>8</b> and <b>11</b> exhibited inhibitory activity on the Wnt/β-catenin signaling pathway in zebrafish embryos at a concentration of 20 μM.
Authors
- Xiaozhi Rong (ORCID: https://orcid.org/0000-0002-8252-6289)
- Chunxiao Sun (ORCID: https://orcid.org/0000-0002-2052-128X)
- Haotian Wang (ORCID: https://orcid.org/0000-0002-3552-8978)
- Meilin Zhu (ORCID: https://orcid.org/0000-0002-2754-1785)
- Shikun Zong
- Dehai Li (ORCID: https://orcid.org/0000-0002-7191-2002)
- Jianfeng Zhou (ORCID: https://orcid.org/0000-0003-0862-7951)
- Yimei Wei
- Jun Xiao (ORCID: https://orcid.org/0000-0002-1799-3948)
- Yi-Xuan Zhang (ORCID: https://orcid.org/0000-0003-4849-3660)
- Yingying Cong
- Zhao-yu Bi (ORCID: https://orcid.org/0009-0001-5828-6094)
Institutions
- Bengbu Medical College (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1021/acs.jnatprod.4c00742
- Citations
- 5
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 2.24
Funders
- National Natural Science Foundation of China
- Anhui Provincial Department of Education
- Natural Science Foundation of Anhui Province