A pilot study examining periodontally healthy middle-aged humans and monkeys display different levels of alveolar bone resorption, gingival inflammatory infiltrate, and salivary microbiota profile
The periodontally healthy middle-aged humans and monkeys display different alveolar bone resorption and gingival inflammatory infiltrate levels. Furthermore, the salivary microbiota profile showed distinctly different oral microbiomes in these two primates. Our results suggest that the difference in alveolar bone status and gingival inflammatory infiltrate in healthy humans and monkeys might be associated with the diversity of the oral microbiome.
Authors
- Janak Lal. Pathak (ORCID: https://orcid.org/0000-0003-2576-443X)
- Zijun Zhou (ORCID: https://orcid.org/0009-0001-2119-193X)
- Bingpeng Lin (ORCID: https://orcid.org/0000-0001-7865-714X)
- Lihong Wu (ORCID: https://orcid.org/0000-0002-4561-9400)
- Learn−Han Lee (ORCID: https://orcid.org/0000-0002-8589-7456)
- Lijing Wang
- Jianming Chen (ORCID: https://orcid.org/0000-0003-0400-3092)
- Mei Zhong (ORCID: https://orcid.org/0009-0009-8797-1267)
- Hongbin Gao (ORCID: https://orcid.org/0000-0001-9232-1212)
- Hooi‐Leng Ser
Institutions
- Monash University Malaysia (MY)
- University of Nottingham Ningbo China (CN)
- Guangdong Pharmaceutical University (CN)
- Guangdong Laboratory Animals Monitoring Institute (CN)
- Stomatology Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1371/journal.pone.0311282
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Sciences
- Natural Science Foundation of Guangdong Province
- Guangdong Medical Research Foundation
- Beijing Institute of Genomics, Chinese Academy of Sciences
- High-level Hospital Construction Project of Guangdong Provincial People's Hospital