Lower activity of cholesteryl ester transfer protein (CETP) and the risk of dementia: a Mendelian randomization analysis
These results suggest that inhibition of CETP may be a viable strategy to treat dementia, with a more pronounced effect expected in APOE-ε4 carriers.
Authors
- Amand F. Schmidt (ORCID: https://orcid.org/0000-0003-1327-0424)
- John J.P. Kastelein (ORCID: https://orcid.org/0000-0003-2018-4532)
- Marc Ditmarsch (ORCID: https://orcid.org/0000-0002-2970-1893)
- Chris Finan (ORCID: https://orcid.org/0000-0002-3319-1937)
- Michael H. Davidson (ORCID: https://orcid.org/0000-0001-9342-1274)
Institutions
- Utrecht University (NL)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Medical Center Utrecht (NL)
- British Heart Foundation (GB)
- University of Chicago (US)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- University of Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1186/s13195-024-01594-6
- Citations
- 8
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 4.58
Funders
- Government of the United Kingdom
- UK Research and Innovation
- National Institute for Health and Care Research
- British Heart Foundation
- University College London
- Rosetrees Trust
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- HORIZON EUROPE Framework Programme