Brain organoids in motor cortex involved in motor output

Motor function is essential in daily life while brain damage in motor system such as stroke would lead to long term motor function deficits. Brain organoids, a novel in vitro stem cell culture technology, offer a new idea for motor function recovery. In this study, we pumped out the motor cortex of forelimbs to mimic brain injury in mice and implanted human brain organoids into the cavity combined with microwire electrodes to simultaneously record neural signals from both the organoids and the host animals. Our findings indicate that the brain organoids can be involved in motor output and the involvement can be improved through behavioral training.