Limited Biomarker Potential for IgG Autoantibodies Reactive to Linear Epitopes in Systemic Lupus Erythematosus or Spondyloarthropathy
In a comprehensive evaluation of the entire human peptidome, highly sensitive and specific IgG autoantibodies were not identified in lupus or spondyloarthropathy. Thus, the pathogenesis of lupus and spondyloarthropathy may not depend upon unique autoantigens, and other types of molecules should be sought as optimal biomarkers in these conditions.
Authors
- Maya F. Amjadi (ORCID: https://orcid.org/0000-0003-3825-3495)
- Srishti Gupta (ORCID: https://orcid.org/0000-0002-6808-7005)
- Aisha M. Mergaert (ORCID: https://orcid.org/0000-0002-8177-9161)
- Zihao Zheng (ORCID: https://orcid.org/0000-0002-9381-5705)
- S. Janna Bashar (ORCID: https://orcid.org/0000-0003-0779-1530)
- Ryan R. Adyniec
- Michael A. Newton (ORCID: https://orcid.org/0000-0001-9038-878X)
- Miriam A. Shelef (ORCID: https://orcid.org/0000-0002-8842-0303)
- Sara S. McCoy (ORCID: https://orcid.org/0000-0002-5293-4185)
Institutions
- University of Wisconsin–Madison (US)
- William S. Middleton Memorial Veterans Hospital (US)
Publication Details
- Journal
- Antibodies
- Published
- 2024-10-12
- DOI
- https://doi.org/10.3390/antib13040087
- Citations
- 2
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Institutes of Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Center for Advancing Translational Sciences
- Congressionally Directed Medical Research Programs