Through-bond and through-space radiofrequency amplification by stimulated emission of radiation
Radio Amplification by Stimulated Emission of Radiation (RASER) is a phenomenon observed during nuclear magnetic resonance (NMR) experiments with strongly negatively polarized systems. This phenomenon may be utilized for the production of very narrow NMR lines, background-free NMR spectroscopy, and excitation-free sensing of chemical transformations. Recently, novel methods of producing RASER by ParaHydrogen-Induced Polarization (PHIP) were introduced. Here, we show that pairwise addition of parahydrogen to various propargylic compounds induces RASER activity of other protons beyond those chemically introduced in the reaction. In high-field PHIP, negative polarization initiating RASER is transferred via intramolecular cross-relaxation. When parahydrogen is added in Earth's field followed by adiabatic transfer to a high field, RASER activity of other protons is induced via both J-couplings and cross-relaxation. This through-bond and through-space induction of RASER holds potential for the ongoing development and expansion of RASER applications and can potentially enhance spectral resolution in two-dimensional NMR spectroscopy techniques.
Authors
- Ivan A. Trofimov (ORCID: https://orcid.org/0000-0002-3773-7490)
- Henri de Maissin (ORCID: https://orcid.org/0000-0003-3505-1572)
- Igor V. Koptyug (ORCID: https://orcid.org/0000-0003-3480-7649)
- Oleg G. Salnikov (ORCID: https://orcid.org/0000-0003-2266-7335)
- Andreas Benjamin Schmidt (ORCID: https://orcid.org/0000-0001-8944-7463)
- Andrey N. Pravdivtsev (ORCID: https://orcid.org/0000-0002-8763-617X)
- Jan‐Bernd Hövener (ORCID: https://orcid.org/0000-0001-7255-7252)
- Eduard Y. Chekmenev (ORCID: https://orcid.org/0000-0002-8745-8801)
- Anna P. Yi (ORCID: https://orcid.org/0000-0003-3717-3450)
Institutions
- University of Freiburg (DE)
- German Cancer Research Center (DE)
- Wayne State University (US)
- Novosibirsk State University (RU)
- Heidelberg University (DE)
- University Medical Center Freiburg (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- The Barbara Ann Karmanos Cancer Institute (US)
- International Tomography Center (RU)
- Clinical Research Center Kiel (DE)
Publication Details
- Journal
- Communications Chemistry
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1038/s42004-024-01313-0
- Citations
- 1
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- National Science Foundation
- U.S. Department of Defense
- Wayne State University
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Russian Science Foundation
- Deutschen Konsortium für Translationale Krebsforschung
- European Regional Development Fund
- National Heart, Lung, and Blood Institute
- National Institute of Biomedical Imaging and Bioengineering
- Division of Chemistry
- Congressionally Directed Medical Research Programs