METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1
The inhibition of lncRNA CRNDE affects the interaction between YTHDC1 and ATG10 mRNA and stabilizes ATG10 mRNA, mediated by METTL3 overexpression. These findings suggest that targeting lncRNA CRNDE to reduce apoptosis, inhibit inflammation, increase ATG10 expression, and enhance autophagy could offer new therapeutic strategies for I/R injury.
Authors
- Youjun Li (ORCID: https://orcid.org/0009-0002-3506-7259)
- Ying Xia (ORCID: https://orcid.org/0000-0001-6706-0911)
- Junwen Jiang
- Liu Wang (ORCID: https://orcid.org/0000-0001-8252-0170)
- You Li (ORCID: https://orcid.org/0000-0002-9611-1877)
- Zhengtao Yu (ORCID: https://orcid.org/0000-0002-4012-461X)
- Jiameng Li (ORCID: https://orcid.org/0000-0002-3652-8849)
Institutions
- Central South University (CN)
- Haikou City People's Hospital (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1186/s13062-024-00536-4
- Citations
- 9
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- National Natural Science Foundation of China