A comprehensive lifestyle index and its associations with DNA methylation and type 2 diabetes among Ghanaian adults: the rodam study
In this explorative epigenome-wide association study among Ghanaians, we identified one DMP and DMR associated with a comprehensive lifestyle index not previously associated with individual lifestyle factors. Based on our findings, we infer that lifestyle factors in combination, affect DNA methylation, thereby influencing the risk of T2DM among Ghanaian adults living in different contexts.
Authors
- Frank P. Mockenhaupt (ORCID: https://orcid.org/0000-0002-8117-5421)
- Charles Hayfron‐Benjamin (ORCID: https://orcid.org/0000-0003-0175-0340)
- Kerstin Klipstein‐Grobusch (ORCID: https://orcid.org/0000-0002-5462-9889)
- Felix P. Chilunga (ORCID: https://orcid.org/0000-0003-4083-001X)
- Carol Akinyi Abidha (ORCID: https://orcid.org/0000-0001-9427-6929)
- Peter Henneman (ORCID: https://orcid.org/0000-0003-2179-7808)
- Charles Agyemang (ORCID: https://orcid.org/0000-0002-3882-7295)
- Ina Danquah (ORCID: https://orcid.org/0000-0003-3222-3498)
- Karlijn Meeks (ORCID: https://orcid.org/0000-0003-3032-405X)
- R. Schindlmayr
- A. Venema
Institutions
- National Institutes of Health (US)
- University of Ghana (GH)
- Johns Hopkins University (US)
- University of the Witwatersrand (ZA)
- Utrecht University (NL)
- Heidelberg University (DE)
- Johns Hopkins Medicine (US)
- University Hospital Heidelberg (DE)
- University Medical Center Utrecht (NL)
- National Human Genome Research Institute (US)
- Amsterdam University Medical Centers (NL)
- German Institute of Human Nutrition (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Amsterdam (NL)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1186/s13148-024-01758-z
- Citations
- 3
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Katholischer Akademischer Ausländer-Dienst
- Universitätsklinikum Heidelberg
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases
- Center for Information Technology