Targeting the LMP1‐ALIX axis in EBV <sup>+</sup> nasopharyngeal carcinoma inhibits immunosuppressive small extracellular vesicle secretion and boosts anti‐tumor immunity
Our findings uncovered the mechanism by which LMP1 interacts with ALIX and PD-L1 to form a trimolecular complex, facilitating PD-L1 loading into ALIX-dependent sEV secretion pathway, ultimately inhibiting the anti-tumor immune response in NPC. This highlights a novel target and prognostic marker for NPC immunotherapy.
Authors
- Yanping Gao (ORCID: https://orcid.org/0009-0002-7254-4480)
- Panwen Sun
- Yajuan Zhou (ORCID: https://orcid.org/0000-0002-2328-1904)
- Rui Bai (ORCID: https://orcid.org/0000-0002-3025-9975)
- Jinru Yang (ORCID: https://orcid.org/0000-0002-8838-5587)
- Yajie Cheng
- Yixin Tan (ORCID: https://orcid.org/0000-0001-5163-2938)
- Tao Gan (ORCID: https://orcid.org/0009-0006-6755-1263)
- Yan Gong (ORCID: https://orcid.org/0000-0002-4805-0459)
- Qiuji Wu (ORCID: https://orcid.org/0000-0002-4655-3108)
- Zhihao Wang (ORCID: https://orcid.org/0000-0003-1561-4040)
- Jian‐Guo Zhang (ORCID: https://orcid.org/0009-0003-0655-3810)
- Xiaoyan Yu (ORCID: https://orcid.org/0000-0003-0351-8393)
- Conghua Xie (ORCID: https://orcid.org/0000-0001-6623-9864)
- Jingyi He (ORCID: https://orcid.org/0000-0002-3640-3093)
- Linzhi Han
- Fajian He (ORCID: https://orcid.org/0009-0002-9798-3199)
- Chunsheng Wang (ORCID: https://orcid.org/0000-0002-4521-3320)
Institutions
- Academy of Medical Sciences (GB)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Hubei Cancer Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cancer Communications
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1002/cac2.12619
- Citations
- 14
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.27
Funders
- National Natural Science Foundation of China