In vivo mapping of postprandial hepatic glucose metabolism using dynamic magnetic resonance spectroscopy combined with stable isotope flux analysis in Roux‐en‐Y gastric bypass adults and non‐operated controls: A case–control study
Exploiting DMI with stable isotope flux analysis, we observed distinct postprandial hepatic glucose trajectories and parameters of glucose-insulin homeostasis in RYGB patients with PBH versus HCs. Despite altered postprandial glucose kinetics and higher insulin exposure, there was no evidence of impaired hepatic glucose uptake or output predisposing to PBH in RYGB patients.
Authors
- Lia Bally (ORCID: https://orcid.org/0000-0003-1993-7672)
- Andreas Melmer (ORCID: https://orcid.org/0000-0001-8085-8768)
- David Herzig (ORCID: https://orcid.org/0000-0003-1028-9445)
- Luc Tappy (ORCID: https://orcid.org/0000-0001-8469-4692)
- Simone Poli (ORCID: https://orcid.org/0000-0001-5676-3187)
- Michele Schiavon (ORCID: https://orcid.org/0000-0003-0590-2399)
- Angeline Buser
- Roland Kreis (ORCID: https://orcid.org/0000-0002-8618-6875)
- Chiara Dalla Man (ORCID: https://orcid.org/0000-0002-4908-0596)
- Naomi F. Lange (ORCID: https://orcid.org/0000-0002-9519-4949)
- Edona Ballabani
- Alessandro Brunasso
Institutions
- University of Bern (CH)
- University of Padua (IT)
- University Hospital of Bern (CH)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1111/dom.16001
- Citations
- 7
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- University of Bern
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung