Pyrazolone-nicotinic acid derivative (4Z)-4-(2-hydroxybenzylidine)-5-methyl-2-(pyridine-3-ylcarbonyl)-2, 4-dihydro-3H-pyrazole-3-one (IIc) as multitarget inhibitor of neurodegeneration and behavioural impairment in Dementia
Finally, we conclude that the pyrazolone-nicotinic acid derivative IIc reversed the scopolamine-induced cognitive and behavioural deficits, attributed to acetylcholinesterase inhibition, neuronal recovery, antioxidant potential, and through downregulating the neuroinflammatory mediators p-NF-kB, cytokine TNF-α, and anti-inflammatory enzyme COX-2.
Authors
- Sadia Sarwar (ORCID: https://orcid.org/0000-0002-2514-8306)
- Madiha Kanwal (ORCID: https://orcid.org/0000-0003-4915-6842)
- Muhammad Junaid Tariq (ORCID: https://orcid.org/0000-0002-8495-8480)
- Sumra Malik (ORCID: https://orcid.org/0000-0002-4120-0549)
- Humaira Nadeem (ORCID: https://orcid.org/0000-0002-0169-0811)
- Amani Alghamdi (ORCID: https://orcid.org/0000-0002-7251-1972)
- Abir Alamro (ORCID: https://orcid.org/0000-0002-6950-0092)
- Saima Maqsood
- Suad A. Alghamdi (ORCID: https://orcid.org/0000-0002-8325-5994)
- Imran Malik (ORCID: https://orcid.org/0000-0003-2802-9529)
- Arif Khan (ORCID: https://orcid.org/0000-0002-6318-8130)
- Aleena Muskan
Institutions
- Prince Sattam Bin Abdulaziz University (SA)
- Riphah International University (PK)
- King Saud University (SA)
- Pharmac (NZ)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1093/jpp/rgae075
- Citations
- 1
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.45