GLS2 reduces the occurrence of epilepsy by affecting mitophagy function in mouse hippocampal neurons
This study proves the GLS2 expression pattern is abnormal in epileptic mice. The function of mitophagy in hippocampal neurons is affected by GLS2, and overexpression of GLS2 can reduce the occurrence of seizure-like events (SLEs) by altering mitophagy function. Thus, GLS2 might control seizures, and our findings provide a fresh avenue for antiepileptic treatment and offer novel insights into treating and preventing epilepsy.
Authors
- Limin Ma (ORCID: https://orcid.org/0000-0002-1299-3367)
- Yunyi Huang
- Xiaolan Yang (ORCID: https://orcid.org/0000-0001-9320-1036)
- Dandan Tan (ORCID: https://orcid.org/0000-0001-5216-6393)
- Minxue Liang (ORCID: https://orcid.org/0000-0003-4840-0559)
- Zhipeng Li (ORCID: https://orcid.org/0009-0003-5496-9319)
- Peng Zhang (ORCID: https://orcid.org/0000-0001-8071-3729)
- Gong Chen (ORCID: https://orcid.org/0000-0002-1857-3670)
- Tao Xu (ORCID: https://orcid.org/0000-0001-6006-5621)
- Yuenan Ban
- Jinxian Yuan (ORCID: https://orcid.org/0000-0002-9280-0851)
- Yuan Gao (ORCID: https://orcid.org/0009-0009-4598-2486)
Institutions
- Chongqing University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1111/cns.70036
- Citations
- 5
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- National Natural Science Foundation of China