THE ROLE OF CYTOKINES IN PREDICTING THE SEVERITY OF THE SYSTEMIC INFLAMMATORY RESPONSE IN PATIENTS WITH COMBINED TRAUMA

In connection with changes in the level of blood cytokines and the development of post-traumatic complications, monitoring these indicators can help in understanding the role of blood cytokines in the development of inflammatory reactions after injury and in the future the possibility of using them as biomarkers to predict the development of the severity of the systemic inflammatory response. Aim. to study the role of cytokines in the development of inflammatory reactions after injury and the possibility of using them as biomarkers. Material and methods. The study included 228 patients with combined trauma of several organ cavities and skeletal injuries. Determination of the concentrations of IL-8, IL-10, TGFβ and IL-4 was carried out using the enzyme immunoassay method in strict accordance with the manufacturer's instructions (R & D Systems, USA). Results As a result of the study, IL-6 increased in patients 1-2 days after injury, as did IL-8, IL-10, TGFβ and IL-4. The levels of IL-6, IL-8, IL-10, TGFβ in patients on days 5-7 remained high and tended to increase, on the contrary, the level of IL-4 tended to decrease. In our study, we detected an increase in TGFβ-1 on days 1-2 after the patient received injury and reached maximum values (TGFβ-1 -134 ng/ml). Conclusion. Changes in the levels of the studied blood cytokines in patients with injuries revealed that there is an imbalance in inflammatory reactions after injury, which was more pronounced in patients in severe conditions and in patients with complications.