EXPERIMENTAL METHODS OF MODELING PREMATURE OVARIAN FAILURE: ADVANTAGES AND DISADVANTAGE

Premature ovarian insufficiency (POI) is a disorder of ovarian function in women under 40 years of age accompanied by amenorrhea or oligomenorrhea for more than 4-6 months with biochemical confirmation of follicle-stimulating hormone (FSH) levels >25 IU/L when assessed twice at 4-week intervals. There are four main types of mouse models of PND: the "chemotherapy" model, the "autoimmune" model, the "psychological stress" model, and the "natural aging" model. The most commonly used is the chemotherapeutic model of NPT induced by cyclophosphamide. Also, such a model can be obtained by induction with trypterigium glycosides (TG), busulfan (BF), DOX, etc. An autoimmune model is developed using ZP3 glycoproteins, a stress mouse model of PNJ is obtained using CUMS, MS, etc. methods. By subcutaneous injection of D-Gal, a natural aging model is generated. Each has its own advantages and disadvantages, relative to ideal criteria mouse models of premature ovarian failure. Based on such considerations, chemotherapeutic models are leading so far, but this mode of induction has a number of side effects such as myelosuppression and bleeding. The aim of this review is to analyze the current data on different murine models of PND, their advantages disadvantages, as well as subtypes and modes of induction.