Cytokine trajectory over time in men and women with HIV on long-term ART
Our study reveals a continuous decline in markers of monocyte/macrophage activation over 6 years of suppressive ART, indicating that long-term treatment may mitigate inflammaging and cardiovascular-related outcomes. The higher levels of sCD14 observed in women are consistent with them having greater innate immune activation than men do.
Authors
- Victor DeGruttola (ORCID: https://orcid.org/0000-0003-2772-6242)
- Eileen P. Scully (ORCID: https://orcid.org/0000-0002-6687-6051)
- Christophe Vanpouille (ORCID: https://orcid.org/0000-0002-5791-1409)
- Alan Landay (ORCID: https://orcid.org/0000-0001-9645-1356)
- Wendy Fitzgerald (ORCID: https://orcid.org/0000-0001-5752-8250)
- Antoine Chaillon (ORCID: https://orcid.org/0000-0001-9490-3857)
- Xin Tu (ORCID: https://orcid.org/0000-0001-6470-980X)
- Miranda L. Lynch (ORCID: https://orcid.org/0000-0001-8604-4431)
- Jonathan Karn (ORCID: https://orcid.org/0000-0002-2900-094X)
- Kathleen M. Weber (ORCID: https://orcid.org/0009-0006-8988-6929)
- Sara Gianella (ORCID: https://orcid.org/0000-0002-9927-0849)
- Alan Wells (ORCID: https://orcid.org/0000-0002-1637-8150)
- Xinlian Zhang (ORCID: https://orcid.org/0000-0002-0913-1205)
Institutions
- Rush University Medical Center (US)
- Hauptman-Woodward Medical Research Institute (US)
- National Institutes of Health (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- University of California San Diego (US)
- Hektoen Institute (US)
- Human Longevity (United States) (US)
- Center for Global Health (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- The University of Texas Medical Branch at Galveston (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- AIDS
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1097/qad.0000000000004033
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- James B. Pendleton Charitable Trust
- National Institutes of Health