Ideal Time to Conduct a Pharmacokinetic Investigation After Delivery to Fully Capture the Effect of Pregnancy on Drug Exposure
Pharmacokinetic investigations on hepatically cleared drugs should not be conducted before the fifth week after delivery to fully characterize the effect of pregnancy on drug exposure. Because physiological changes remain after delivery, early measurements can underestimate the pregnancy effect on pharmacokinetics, leading to suboptimal dosing recommendations during pregnancy.
Authors
- Mattia Berton (ORCID: https://orcid.org/0000-0001-9450-2228)
- Sara Bettonte (ORCID: https://orcid.org/0000-0002-7532-7898)
- Felix Stader (ORCID: https://orcid.org/0000-0002-4223-6754)
- Catia Marzolini (ORCID: https://orcid.org/0000-0002-2312-7050)
- Manuel Battegay (ORCID: https://orcid.org/0000-0002-6638-3679)
Institutions
- University of Liverpool (GB)
- University of Basel (CH)
- University Hospital of Basel (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1093/ofid/ofae585
- Citations
- 1
- Primary Topic
- Pregnancy and Medication Impact
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- Pfizer
- Gilead Sciences
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung