Defining Echocardiographic Degrees of Right Heart Size and Function in Pulmonary Vascular Disease From the PVDOMICS Study
In this well-characterized sample of adults with diverse etiologies and varying PVD severity, we define categories of abnormal right heart chamber size and function. Further, we demonstrate a stepwise relationship between these categories of abnormal morphology and function and all-cause mortality. Defining grades of RV dysfunction in individuals with known PVD has important clinical implications for monitoring disease progression and response to therapies.
Authors
- Evan L. Brittain (ORCID: https://orcid.org/0000-0001-5843-3392)
- Paul M. Hassoun (ORCID: https://orcid.org/0000-0003-0601-4975)
- James D. Thomas (ORCID: https://orcid.org/0000-0002-8132-2903)
- Gerald J. Beck (ORCID: https://orcid.org/0000-0002-9514-591X)
- Serpil C. Erzurum (ORCID: https://orcid.org/0000-0001-5202-9065)
- Deborah Kwon (ORCID: https://orcid.org/0000-0003-2191-4111)
- Stephen C. Mathai (ORCID: https://orcid.org/0000-0003-3188-7209)
- W.H. Wilson Tang (ORCID: https://orcid.org/0000-0002-8335-735X)
- Caitlin Chiu (ORCID: https://orcid.org/0009-0005-9506-7981)
- Christine Jellis (ORCID: https://orcid.org/0000-0002-8610-0533)
- Catherine E. Simpson (ORCID: https://orcid.org/0000-0002-2388-5660)
- Evelyn M. Horn (ORCID: https://orcid.org/0000-0002-5751-9415)
- Monica Mukherjee (ORCID: https://orcid.org/0000-0001-6088-0773)
- Vivek Jani (ORCID: https://orcid.org/0000-0002-3811-4973)
- Anna R. Hemnes (ORCID: https://orcid.org/0000-0002-2755-5845)
- Jane A. Leopold (ORCID: https://orcid.org/0000-0003-0598-8882)
- Lisa R. Yanek (ORCID: https://orcid.org/0000-0001-7117-1075)
- Franz Rischard (ORCID: https://orcid.org/0000-0002-6861-8304)
- Nicholas S. Hill (ORCID: https://orcid.org/0000-0002-8242-8339)
- Benjamin H. Freed (ORCID: https://orcid.org/0000-0003-1075-5047)
- Robert P. Frantz (ORCID: https://orcid.org/0000-0003-4128-3978)
- Margaret Park (ORCID: https://orcid.org/0000-0003-4074-8630)
- Hannah Agoglia
- Erika B. Rosenzweig (ORCID: https://orcid.org/0000-0003-4849-214X)
- Jiwon Kim (ORCID: https://orcid.org/0000-0002-8420-8604)
Institutions
- Northwestern University (US)
- Tufts University (US)
- Brigham and Women's Hospital (US)
- Cleveland Clinic (US)
- Mayo Clinic (US)
- University of Arizona (US)
- Johns Hopkins University (US)
- Vanderbilt University (US)
- Cornell University (US)
- Johns Hopkins Medicine (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Columbia University (US)
Publication Details
- Journal
- Circulation Cardiovascular Imaging
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1161/circimaging.124.017074
- Citations
- 15
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.28
Funders
- United Therapeutics Corporation
- Tenax Therapeutics