NEUROENDOCRINE TUMORS OF THE GENITOURINARY TRACT - A CLINICAL AND PATHOLOGIC REVIEW

Abstract Introduction/Objective Neuroendocrine tumors (NETs) of the genitourinary (GU) tract are rarely seen during daily surgical pathology sign-out sessions and comprise a heterogeneous group of neoplasms. We undertook a retrospective study to assess the clinical and pathologic characteristics of this unusual group of neoplasms involving the GU tract. Methods/Case Report We performed a retrospective review of the surgical pathology files for NETs of the GU tract between July 1993 and December 2021. Chart review was performed for the clinical and pathologic findings. Results (if a Case Study enter NA) A total of 26 patients were identified. There were 18 males and 8 females ranging in age from 43 to 94 years (mean age 69 years). 19/26 (73%) cases were primary tumors; 9 bladder small cell carcinoma, 5 prostatic small cell carcinoma, 4 bladder paragangliomas, and 1 case of small cell carcinoma of the renal pelvis. 7/26 (27%) cases were metastatic tumors; 5 Merkel carcinoma (3 urinary bladders, 2 testes), and 2 small cell carcinoma of the lung to the kidney. Conclusion The majority of NETs of the GU are primary and urinary bladder to be the most common site. Merkel cell carcinoma appears to have a tendency to metastasize to the GU tract, especially to the testis.