Gene expression profiles in placenta and their association with anesthesia, delivery mode and maternal diabetes
The findings reveal suppression of immune pathways and upregulation of ribosome activity in the placenta by maternal diabetes highlighting the importance of confounding factors when examining cell and tissue expression profiles. Further studies should determine whether the observed gene expression differences are related to underlying causes for cesarean section deliveries.
Authors
- Annette I. Garbe
- Ramona Lickert
- Ezio E. Bonifacio (ORCID: https://orcid.org/0000-0002-8704-4713)
- Bassam Aljani
- Fabian Rost (ORCID: https://orcid.org/0000-0001-6466-2589)
- Anne Eugster (ORCID: https://orcid.org/0000-0001-8009-5959)
- Anette-Gabriele Ziegler
- Eva‐Maria Sedlmeier
Institutions
- Center for Environmental Health (US)
- Helmholtz Zentrum München (DE)
- Center for Systems Biology Dresden (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- Max Planck Institute of Molecular Cell Biology and Genetics (DE)
- German Center for Diabetes Research (DE)
- Paul Langerhans Institute Dresden (DE)
- Heinrich Heine University Düsseldorf (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Placenta
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1016/j.placenta.2024.10.008
- Citations
- 2
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Leona M. and Harry B. Helmsley Charitable Trust
- Novo Nordisk
- European Association for the Study of Diabetes
- Novo Nordisk Fonden