Hypoxic glioma-derived exosomal miR-25-3p promotes macrophage M2 polarization by activating the PI3K-AKT-mTOR signaling pathway
Our study reveals that miR-25-3p from hypoxic glioma cells is delivered to macrophages via exosomes as a mediator, promoting M2 polarization of macrophages through the miR-25-3p/PHLPP2/PI3K-AKT signaling pathway. This study suggests that targeted interventions to modulate miR-25-3p expression, transmission, or inhibition of PI3K-AKT pathway activation can disrupt the immune-suppressive microenvironment, providing a novel approach for immunotherapy in gliomas.
Authors
- Zhiwei Xue (ORCID: https://orcid.org/0000-0002-9761-0838)
- Junzhi Liu (ORCID: https://orcid.org/0000-0001-7146-0942)
- Xuchen Liu (ORCID: https://orcid.org/0000-0001-7054-743X)
- Jian Wang (ORCID: https://orcid.org/0000-0002-9482-5227)
- Xingang Li (ORCID: https://orcid.org/0000-0002-0878-0211)
- Donghai Wang (ORCID: https://orcid.org/0000-0003-4273-6115)
- Jiwei Wang (ORCID: https://orcid.org/0000-0003-4145-4781)
- Bin Huang (ORCID: https://orcid.org/0000-0002-0944-7648)
- Xing Wei (ORCID: https://orcid.org/0000-0002-5154-1363)
- Yanzhao Wu
- Fang Mu
- Jiangli Zhao
Institutions
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
- Dezhou University (CN)
- University of Bergen (NO)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1186/s12951-024-02888-5
- Citations
- 46
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 10.76
Funders
- Shandong University
- National Natural Science Foundation of China