P1.02D.01 Exosome PAICS Enhances Radioresistance in NSCLC by Mitigating Radiation-Induced DNA Damage and Facilitating Immune Evasion

Radioresistance in NSCLC is not solely a consequence of tumor cell adaptation but also involves significant alterations within the tumor microenvironment, including changes in immune cell dynamics. Tumor-derived exosomes play a critical role in this adaptive resistance, influencing not just the tumor cells but also the immune cells. Unraveling the molecular mechanisms of exosome-mediated radioresistance is crucial for identifying novel targets that can sensitize tumors to radiotherapy and serve as predictive markers for treatment response.