Virus Load Kinetics in Lassa Fever Patients Treated With Ribavirin: A Retrospective Cohort Study From Southern Nigeria
Our study demonstrates that the Ct value on admission has prognostic value and Lassa fever patients treated with ribavirin typically clear the virus within 3-4 weeks of hospitalization. This kinetics has implications for the design of clinical case management and future clinical trial protocols.
Authors
- Sylvanus Okogbenin (ORCID: https://orcid.org/0000-0001-7882-8316)
- George O. Akpede (ORCID: https://orcid.org/0000-0003-1035-4067)
- Elisa Pallasch
- Lisa Oestereich (ORCID: https://orcid.org/0000-0003-0098-7485)
- Wilson Ovienria (ORCID: https://orcid.org/0000-0002-2532-7099)
- Cyril Erameh (ORCID: https://orcid.org/0000-0001-7783-2495)
- Nosa Akpede
- Sophie Duraffour (ORCID: https://orcid.org/0000-0002-1239-4372)
- Ekaete Tobin (ORCID: https://orcid.org/0000-0001-5059-807X)
- Ephraim Ogbaini-Emovon (ORCID: https://orcid.org/0000-0001-5407-1152)
- Julia Hinzmann
- Emmanuel Friday Osagiede (ORCID: https://orcid.org/0000-0001-5254-6783)
- Martha Okonofua (ORCID: https://orcid.org/0000-0003-2001-9887)
- Christian Ehigbor Erohubie
- Stephan Günther (ORCID: https://orcid.org/0000-0002-6562-0230)
- Ikponmwonsa Odia
- Ralf Krumkamp (ORCID: https://orcid.org/0000-0003-3053-476X)
- Meike Pahlmann (ORCID: https://orcid.org/0000-0001-8423-4178)
- Peter Akhideno (ORCID: https://orcid.org/0000-0002-4736-7964)
- Kingsley Chiedozie Ojide
- Maxy A C Odike
- Mojeed Olaitan Rafiu (ORCID: https://orcid.org/0000-0001-6289-0967)
- Danny Asogun
- Anke Thielebein
- Chukwuemeka P. Azubuike (ORCID: https://orcid.org/0000-0002-2634-8537)
- Jonas Müller
- Anieno Elkanem
- Peter O. Okokhere (ORCID: https://orcid.org/0000-0003-3007-2868)
- Reuben Eifediyi (ORCID: https://orcid.org/0009-0007-7877-3045)
- Donatus I. Adomeh
- Jacqueline Agbukor
- Christopher Ojemiega Iruolagbe
- Deeba Ahmed
- Ekene B Muoebenam
- Kelly Iraoya
- Osahogie Ediawe
- Joseph Okoguale
Institutions
- German Center for Infection Research (DE)
- Irrua Specialist Teaching Hospital (NG)
- Federal Teaching Hospital Abakaliki (NG)
- Bernhard Nocht Institute for Tropical Medicine (DE)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1093/ofid/ofae575
- Citations
- 5
- Primary Topic
- Viral Infections and Outbreaks Research
- Type
- article
- Field-Weighted Citation Impact
- 1.95
Funders
- Deutsche Forschungsgemeinschaft
- Leibniz-Gemeinschaft
- European and Developing Countries Clinical Trials Partnership