Evidence of apoptosis as an early event leading to cyclophosphamide-induced primordial follicle depletion in a prepubertal mouse model
Our results indicated that cyclophosphamide-induced acute ovarian primordial follicle depletion was mainly related to apoptotic pathways. No evidence of follicle activation was found, neither through changes in the expression of related genes to follicle activation nor in the density of growing follicles. Further validation at protein level in 4-HC-treated prepubertal mice ovaries at 24 h confirmed these observations.
Authors
- Amandine Anastácio (ORCID: https://orcid.org/0000-0002-2170-5806)
- Arturo Reyes Palomares (ORCID: https://orcid.org/0000-0001-5820-3490)
- Kenny A. Rodriguez‐Wallberg (ORCID: https://orcid.org/0000-0003-4378-6181)
- Xia Hao (ORCID: https://orcid.org/0009-0006-6791-9603)
- Kui Liu (ORCID: https://orcid.org/0000-0002-7519-3332)
Institutions
- Karolinska University Hospital (SE)
- Chinese University of Hong Kong (HK)
- Karolinska Institutet (SE)
- University of Hong Kong - Shenzhen Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-10-14
- DOI
- https://doi.org/10.3389/fendo.2024.1322592
- Citations
- 7
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 3.80
Funders
- National Natural Science Foundation of China
- Cancerfonden
- Karolinska Institutet
- Stockholms Läns Landsting
- Vetenskapsrådet
- China Scholarship Council
- Barncancerfonden