A new bicyclo [3.3.1]nonadienemethanol-type lignan from the leaves of <i>Taxus wallichiana</i> Zucc.
Following an α-glucosidase inhibitory activity-guided phytochemical study, a rare new bicyclo[3.3.1]nonadienemethanol-type lignan named 9,9'-oxidolanceolatanin B (<b>1</b>) and four known lignans, lanceolatanin B (<b>2</b>), pinoresinol (<b>3</b>), syringaresinol (<b>4</b>), and medioresinol (<b>5</b>), were isolated from a CHCl<sub>3</sub>-soluble fraction of <i>Taxus wallichiana</i> Zucc. leaves. The absolute configuration of 9,9'-oxidolanceolatanin B was elucidated based on NMR spectroscopic interpretation and ECD data. All isolated compounds <b>1</b>-<b>5</b> showed stronger α-glucosidase inhibitory potency than the positive control, acarbose. This data could support the conceit that <i>Taxus wallichiana</i> leaves could be a promising source for plant-based anti-diabetic drug discovery.
Authors
- Tho Huu Le (ORCID: https://orcid.org/0000-0001-9623-2858)
- Nhan Trung Nguyen (ORCID: https://orcid.org/0000-0001-5142-4573)
- Phu Hoang Dang (ORCID: https://orcid.org/0000-0002-4989-9315)
- Mai Thanh Thi Nguyen (ORCID: https://orcid.org/0000-0001-8006-4028)
- Tu Hoai Tran (ORCID: https://orcid.org/0000-0001-9950-4038)
Institutions
- Vietnam National University Ho Chi Minh City (VN)
- Ho Chi Minh City University of Science (VN)
- Drug Discovery Laboratory (Norway) (NO)
Publication Details
- Journal
- Natural Product Research
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1080/14786419.2024.2414407
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00