[Single nucleotide polymorphism heritability of non-syndromic cleft lip with or without cleft palate in Chinese population].
Our study sheds light on the intricate interplay between common genetic variations and the risk of NSCL/P in the Chinese population. By elucidating the SNP heritability landscape across different genomic regions, we contribute valuable insights into the genetic basis of NSCL/P. The significant enrichment of SNP heritability within enhancer and super enhancer regions underscores the potential role of these regulatory elements in shaping the genetic susceptibility to NSCL/P. This paves the way for further research aimed at uncovering novel genetic pathogenic factors underlying NSCL/P pathogenesis.
Authors
- E C Xue (ORCID: https://orcid.org/0009-0009-4717-0633)
- Xueheng Wang
- Yiqun Wu (ORCID: https://orcid.org/0000-0002-5554-1678)
- Siyue Wang (ORCID: https://orcid.org/0000-0002-0186-7955)
- Zhibo Zhou (ORCID: https://orcid.org/0000-0001-5476-9921)
- Dafang Chen (ORCID: https://orcid.org/0000-0001-8226-5413)
- Xi Chen (ORCID: https://orcid.org/0000-0003-0590-5717)
- Jing Li (ORCID: https://orcid.org/0000-0001-9392-6600)
- Nan Li (ORCID: https://orcid.org/0000-0001-5490-322X)
- Jin Li (ORCID: https://orcid.org/0000-0001-9201-2321)
- Mengying Wang (ORCID: https://orcid.org/0000-0003-0162-5355)
- Xueying Qin (ORCID: https://orcid.org/0000-0003-3271-8618)
- Yonghua Hu (ORCID: https://orcid.org/0000-0003-1631-3952)
- Tao Wu (ORCID: https://orcid.org/0000-0001-9456-4082)
- Hongping Zhu
Institutions
- Peking University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-10-18
- DOI
- https://doi.org/10.19723/j.issn.1671-167x.2024.05.004
- Citations
- 1
- Primary Topic
- Cleft Lip and Palate Research
- Type
- article