Physical and mental health trajectories: A longitudinal SF-36 analysis in Alpha-1 antitrypsin deficiency-associated COPD
At baseline, mental HRQoL scores were higher than physical HRQoL scores, indicating better mental health than physical health in this cohort with AATD-associated lung disease. Stable HRQoL with a slight improvement in mental scores over time and a small decrease in physical scores may be a unique feature of this cohort. Further studies are needed to correlate these findings with disease-specific instruments and patient physiology.
Authors
- Charlie Strange (ORCID: https://orcid.org/0000-0002-8109-8067)
- Robert A. Sandhaus (ORCID: https://orcid.org/0000-0002-7937-2485)
- Kristen E. Holm (ORCID: https://orcid.org/0000-0003-2280-2322)
- Radmila Choate (ORCID: https://orcid.org/0000-0002-0540-8377)
- David M. Mannino (ORCID: https://orcid.org/0000-0003-3646-7828)
Institutions
- University of Kentucky (US)
- Medical University of South Carolina (US)
- National Jewish Health (US)
- AlphaNet (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Respiratory Medicine
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1016/j.rmed.2024.107838
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00