Oleic Acid Inhibits SDC4 and Promotes Ferroptosis in Lung Cancer Through GPX4/ACSL4
This study confirmed that OA could inhibit SDC4 expression and promote the occurrence of ferroptosis in A549 cells and H1299 cells through the GPX4/ACSL4 pathway, providing an effective basis for the use of drugs targeting ferroptosis in lung cancer treatment.
Authors
- Hua-Ji Qie
- Kaiyue Xu
- Yapei Xu
- Junjian Dong (ORCID: https://orcid.org/0009-0001-5202-144X)
- Li Li (ORCID: https://orcid.org/0000-0002-0208-7475)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-8811-5552)
- Dehui Li (ORCID: https://orcid.org/0000-0001-7963-9410)
- Fei Qi (ORCID: https://orcid.org/0000-0002-4853-2845)
- Shiye Du
Institutions
- Chengde Medical University (CN)
- Hebei General Hospital (CN)
- Hebei University of Chinese Medicine (CN)
Publication Details
- Journal
- The Clinical Respiratory Journal
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1111/crj.70014
- Citations
- 16
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 6.70