Frontispiz: Discovery, Total Synthesis, and Anti‐Inflammatory Evaluation of Naturally Occurring Naphthopyrone‐Macrolide Hybrids as Potent NLRP3 Inflammasome Inhibitors
Natural Products. The NLRP3 inflammasome plays a crucial role in regulating the innate immune system and inflammatory signaling. In their Research Article (e202405860), Dehai Li and co-workers report that a naphthopyrone-macrolide hybrid derived from Antarctic fungus serves as a potent NLRP3 inflammasome inhibitor.
Authors
- Yuqi Jiang (ORCID: https://orcid.org/0000-0002-6612-4888)
- Qian Che (ORCID: https://orcid.org/0000-0003-0610-1593)
- Mudassir Shah (ORCID: https://orcid.org/0000-0001-8797-7540)
- Chunxiao Sun (ORCID: https://orcid.org/0000-0002-2052-128X)
- Simin Sun (ORCID: https://orcid.org/0009-0002-9398-6886)
- Tianjiao Zhu (ORCID: https://orcid.org/0000-0003-4185-5593)
- Guojian Zhang (ORCID: https://orcid.org/0000-0002-4976-8083)
- Dehai Li (ORCID: https://orcid.org/0000-0002-7191-2002)
- De Wang (ORCID: https://orcid.org/0000-0002-3737-6621)
- Changlong Li (ORCID: https://orcid.org/0000-0001-6832-785X)
- Jiaqi Lin (ORCID: https://orcid.org/0000-0003-0209-8817)
- Luning Zhou (ORCID: https://orcid.org/0000-0001-5283-4769)
- Liping Li (ORCID: https://orcid.org/0009-0002-6251-7198)
- Wenxue Wang (ORCID: https://orcid.org/0000-0002-9137-8302)
Institutions
- Abbottabad University of Science and Technology (PK)
- Qingdao National Laboratory for Marine Science and Technology (CN)
- Marine Biomedical Research Institute of Qingdao (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Angewandte Chemie
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1002/ange.202484361
- Primary Topic
- Synthesis of heterocyclic compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00