Pharmacogenetics of tuberculosis treatment toxicity and effectiveness in a large Brazilian cohort
In a clinical cohort representing three regions of Brazil, NAT2 acetylator status was associated with risk for treatment-related adverse events. Additional significant polymorphisms merit investigation in larger study populations, particularly regarding risk of treatment failure/recurrence.
Authors
- Megan Turner (ORCID: https://orcid.org/0000-0001-5180-2773)
- Bruno B. Andrade (ORCID: https://orcid.org/0000-0001-6833-3811)
- Valéria C. Rolla (ORCID: https://orcid.org/0000-0002-0841-1408)
- David W. Haas (ORCID: https://orcid.org/0000-0002-5813-1594)
- James Jaworski (ORCID: https://orcid.org/0009-0009-2852-4088)
- Afrânio Lineu Kritski (ORCID: https://orcid.org/0000-0002-5900-6007)
- Marina C. Figueiredo (ORCID: https://orcid.org/0000-0002-0671-398X)
- Digna R. Velez Edwards (ORCID: https://orcid.org/0000-0001-5293-0056)
- Adalberto Rezende Santos (ORCID: https://orcid.org/0000-0002-9514-4589)
- Marcelo Cordeiro‐Santos (ORCID: https://orcid.org/0000-0002-7140-7145)
- Timothy R. Sterling (ORCID: https://orcid.org/0000-0002-4822-6979)
- Gustavo Amorim (ORCID: https://orcid.org/0000-0002-2941-5360)
- H. J. Yang (ORCID: https://orcid.org/0009-0004-8274-9863)
Institutions
- Meharry Medical College (US)
- Universidade Federal do Rio de Janeiro (BR)
- Escola Bahiana de Medicina e Saúde Pública (BR)
- MRC Laboratory of Molecular Biology (GB)
- Laureate Education (US)
- Fundação de Medicina Tropical (BR)
- Fundo Brasil (BR)
- Instituto Evandro Chagas (BR)
- Universidade do Estado do Amazonas (BR)
- Universitario Francisco de Asís (UY)
- Universidade Salvador (BR)
- Fundação Oswaldo Cruz (BR)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Pharmacogenetics and Genomics
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1097/fpc.0000000000000552
- Citations
- 7
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.72