Polygenic liabilities and treatment trajectories in early-onset depression: a Danish register-based study
We found significant associations between polygenic liabilities for psychiatric disorders and treatment trajectories in patients with secondary-treated early-onset MDD. These findings help elucidate the relationship between a patient's genetics and their clinical course; however, the effect sizes are small and therefore unlikely to have predictive value in clinical settings.
Authors
- John Joseph McGrath (ORCID: https://orcid.org/0000-0002-4792-6068)
- Jette Steinbach (ORCID: https://orcid.org/0000-0003-0553-6480)
- Alisha S. M. Hall (ORCID: https://orcid.org/0000-0002-1684-6663)
- Anita Thapar (ORCID: https://orcid.org/0000-0002-3689-737X)
- Jessica Mundy (ORCID: https://orcid.org/0000-0001-5513-8902)
- Anders D. Børglum (ORCID: https://orcid.org/0000-0001-8627-7219)
- Merete Nordentoft (ORCID: https://orcid.org/0000-0003-4895-7023)
- Thomas D. Als (ORCID: https://orcid.org/0000-0002-2963-1928)
- Thomas Werge (ORCID: https://orcid.org/0000-0003-1829-0766)
- Esben Agerbo (ORCID: https://orcid.org/0000-0002-2849-524X)
- Clara Albiñana (ORCID: https://orcid.org/0000-0002-3166-4120)
- Bjarni Jóhann Vilhjálmsson (ORCID: https://orcid.org/0000-0003-2277-9249)
- Katherine L. Musliner (ORCID: https://orcid.org/0000-0001-6198-4953)
- Preben Bo Mortensen (ORCID: https://orcid.org/0000-0002-4782-1450)
Institutions
- Broad Institute (US)
- University of Copenhagen (DK)
- The University of Queensland (AU)
- Aarhus University (DK)
- Park Centre for Mental Health (AU)
- Mental Health Services (DK)
- Aarhus University Hospital (DK)
- Foundation Center (US)
- Queensland Centre for Mental Health Research (AU)
- Novo Nordisk (United States) (US)
- Lundbeck Foundation (DK)
- Capital Region of Denmark (DK)
- Cardiff University (GB)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1017/s0033291724002186
- Citations
- 5
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.75
Funders
- Aarhus Universitet
- Broad Institute
- Lundbeckfonden
- Novo Nordisk
- H. Lundbeck A/S
- National Institutes of Health
- National Institute of Mental Health