Impact of provision of abdominal aortic calcification results on fruit and vegetable intake: 12-week randomized phase 2 controlled trial

Provision of non-invasive vascular imaging results to individuals has been shown to improve cardiovascular disease risk factor control: its impact on diet remains uncertain. In this two-arm, single-blind, parallel, 12-week randomized controlled trial, 240 participants, 57.5% females aged 60-80 y had abdominal aortic calcification and clinical assessments performed at a hospital clinic. Participants were randomized 1:1 to receive (intervention n = 121) or not (control n = 119) their calcification results. Both groups received educational resources on cardiovascular disease risk control and were unblinded to the intervention. Outcome measures were performed at baseline and 12 weeks. The primary outcomes of the study were changes in fruit and vegetable intake measures over 12 weeks assessed using plasma carotenoid concentrations (biomarkers of FV intake) and a food frequency questionnaire. Secondary outcomes included 12-week changes in other aspects of the diet, physical activity, body weight, blood pressure, heart rate, lipid profile, glucose concentrations, estimated cardiovascular disease risk score, and medication use. Between-group differences were tested using linear mixed-effects regression. There were no between-group differences in the primary outcomes at 12 weeks: plasma carotenoids (mean difference +0.03 µg/mL [95%CI -0.06, 0.13]) and fruit and vegetable intakes (+18 g/d [-37, 72]). However, the provision of calcification results led to between-group differences in serum total (-0.22 mmol/L [-0.41, -0.04]) and non-HDL (-0.19 mmol/L [-0.35, -0.03]) cholesterol, and estimated cardiovascular disease risk score (-0.24% [-0.47, -0.02]). No between-group differences were seen for other secondary outcomes. In this work, providing vascular imaging results did not improve diet but did improve some cardiovascular disease risk factors (Australian and New Zealand Clinical Trials Registry ACTRN12618001087246).

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Journal
Nature Communications
Published
2024-10-14
DOI
https://doi.org/10.1038/s41467-024-52172-1
Citations
6
Primary Topic
Cardiovascular Health and Disease Prevention
Type
article
Field-Weighted Citation Impact
2.41

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article

Impact of provision of abdominal aortic calcification results on fruit and vegetable intake: 12-week randomized phase 2 controlled trial

Abadi Kahsu Gebre, Moira Sim, Paweł Szulc, Joshua R. Lewis et al.
6 citations
Nature Communications
Cardiovascular Health and Disease Prevention
2.41
article

Impact of provision of abdominal aortic calcification results on fruit and vegetable intake: 12-week randomized phase 2 controlled trial

Abadi Kahsu Gebre, Moira Sim, Paweł Szulc, Joshua R. Lewis, Mandy Stanley, Douglas P. Kiel, Richard John Woodman, Emma Connolly, Nicola P. Bondonno, Catherine P. Bondonno, Jonathan M. Hodgson, Lauren C. Blekkenhorst, Marc Sim, Shelby Mullin, Kay L. Cox, Peter L. Thompson, Lisa G. Wood, Markus Peter Schlaich, Evan J. Williams, James A. Dimmock, Ben Jackson, Robin M. Daly, Kun Zhu, John T. Schousboe, Wai H. Lim, Simone Radavelli‐Bagatini, Amanda Devine, Jack Dalla Via
article en
6 citations

Abstract

Provision of non-invasive vascular imaging results to individuals has been shown to improve cardiovascular disease risk factor control: its impact on diet remains uncertain. In this two-arm, single-blind, parallel, 12-week randomized controlled trial, 240 participants, 57.5% females aged 60-80 y had abdominal aortic calcification and clinical assessments performed at a hospital clinic. Participants were randomized 1:1 to receive (intervention n = 121) or not (control n = 119) their calcification results. Both groups received educational resources on cardiovascular disease risk control and were unblinded to the intervention. Outcome measures were performed at baseline and 12 weeks. The primary outcomes of the study were changes in fruit and vegetable intake measures over 12 weeks assessed using plasma carotenoid concentrations (biomarkers of FV intake) and a food frequency questionnaire. Secondary outcomes included 12-week changes in other aspects of the diet, physical activity, body weight, blood pressure, heart rate, lipid profile, glucose concentrations, estimated cardiovascular disease risk score, and medication use. Between-group differences were tested using linear mixed-effects regression. There were no between-group differences in the primary outcomes at 12 weeks: plasma carotenoids (mean difference +0.03 µg/mL [95%CI -0.06, 0.13]) and fruit and vegetable intakes (+18 g/d [-37, 72]). However, the provision of calcification results led to between-group differences in serum total (-0.22 mmol/L [-0.41, -0.04]) and non-HDL (-0.19 mmol/L [-0.35, -0.03]) cholesterol, and estimated cardiovascular disease risk score (-0.24% [-0.47, -0.02]). No between-group differences were seen for other secondary outcomes. In this work, providing vascular imaging results did not improve diet but did improve some cardiovascular disease risk factors (Australian and New Zealand Clinical Trials Registry ACTRN12618001087246).

Nature CommunicationsVol. 15(1)
Université Claude Bernard Lyon 1 (FR), Edith Cowan University (AU), The University of Sydney (AU), University of Minnesota (US), Beth Israel Deaconess Medical Center (US), Harvard University (US), Deakin University (AU), Inserm (FR), Flinders University (AU), The Kids Research Institute Australia (AU), The University of Western Australia (AU), Royal Perth Hospital (AU), Sir Charles Gairdner Hospital (AU), Children's Hospital at Westmead (AU), Hospices Civils de Lyon (FR), Park Nicollet Clinic (US), Hebrew SeniorLife (US), Danish Cancer Society (DK), HealthPartners (US), University of Newcastle Australia (AU), James Cook University (AU)
National Heart Foundation of Australia, Edith Cowan University, Medical Research Council, National Health and Medical Research Council
Zero hunger
Openalex Percentile: Top 10%
Cardiovascular Health and Disease Prevention
2.41
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