Long-Term Human Immune Reconstitution, T-Cell Development, and Immune Reactivity in Mice Lacking the Murine Major Histocompatibility Complex: Validation with Cellular and Gene Expression Profiles
Human T-cell development and reactivity are independent of the expression of murine MHCs in humanized mice. Therefore, humanized NSG-DKO is a promising new model for studying human immune responses, as it abrogates the xenograft mouse MHC interference.
Authors
- Martin Thelen (ORCID: https://orcid.org/0000-0002-2785-9726)
- Renata Stripecke (ORCID: https://orcid.org/0000-0001-7756-8460)
- Constantin von Kaisenberg (ORCID: https://orcid.org/0000-0001-5554-1937)
- Johannes Koenig
- Eugen Bauer (ORCID: https://orcid.org/0000-0002-8268-5933)
- Michael Damrat
- Kerstin Wennhold (ORCID: https://orcid.org/0000-0001-5539-7226)
- Milita Darguzyte (ORCID: https://orcid.org/0000-0002-8213-8075)
- Leonard D. Shultz (ORCID: https://orcid.org/0000-0002-4868-1031)
- Nima Abedpour (ORCID: https://orcid.org/0000-0002-2933-8035)
- Philipp Antczak (ORCID: https://orcid.org/0000-0001-9600-7757)
- Brian W. Soper
- Frank Klawonn (ORCID: https://orcid.org/0000-0001-9613-182X)
- Andreas Schneider (ORCID: https://orcid.org/0000-0003-1623-7988)
- Steven Roger Talbot (ORCID: https://orcid.org/0000-0002-9062-4065)
- Sebastian J. Theobald
- Hans Schlößer (ORCID: https://orcid.org/0000-0002-1304-7719)
- Daniel Bachurski (ORCID: https://orcid.org/0000-0001-9168-9680)
- María A. García-Márquez (ORCID: https://orcid.org/0000-0002-5923-5942)
- Tobias Braun (ORCID: https://orcid.org/0000-0002-3910-2886)
- Jan-Malte Kleid (ORCID: https://orcid.org/0000-0002-1400-653X)
- Patrick Hoelker (ORCID: https://orcid.org/0000-0002-9464-7985)
- Rahil Gholamipoorfard
- Masudur Rahman (ORCID: https://orcid.org/0009-0006-9429-6405)
Institutions
- University of Cologne (DE)
- Ostfalia University of Applied Sciences (DE)
- Medizinische Hochschule Hannover (DE)
- Düsseldorf University Hospital (DE)
- Jackson Laboratory (US)
- German Center for Infection Research (DE)
- Helmholtz Centre for Infection Research (DE)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- University Hospital Cologne (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Cells
- Published
- 2024-10-12
- DOI
- https://doi.org/10.3390/cells13201686
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jackson Laboratory
- Deutsches Zentrum für Infektionsforschung
- Medizinischen Hochschule Hannover
- Deutsche Krebshilfe
- Universität zu Köln
- Center for Molecular Medicine Cologne, University of Cologne