Quantitative CT imaging and radiation-absorbed dose estimations of 166Ho microspheres: paving the way for clinical application
Local injection of <sup>166</sup>Ho-MS enables high local tumor doses while sparing surrounding tissue. CT enables imaging-based quantification and radiation-absorbed dose estimation of concentrated Ho in vivo, essential for treatment safety and efficacy. Two different CT scanners and multiple acquisition and reconstruction parameters showed near-perfect linearity between radiodensity and Ho concentration. The most accurate Ho recoveries on CT were 102 ± 11% in five phantoms and 98 ± 31% in seven canine patients using thresholding methods. Dose estimations and volume histograms were successfully implemented for clinical application using a dose point kernel based on Monte Carlo simulations.
Authors
- Gerrit van de Maat
- Nienke Johanna Maria Klaassen (ORCID: https://orcid.org/0000-0001-8898-4005)
- Robin Bruggink (ORCID: https://orcid.org/0000-0003-0316-648X)
- Alexandra Arranja
- J. Frank W. Nijsen (ORCID: https://orcid.org/0000-0001-7625-2253)
- Milou Boswinkel
- Irene A. Schaafsma
- Jan Willem Hesselink (ORCID: https://orcid.org/0000-0001-6378-9721)
- Chiron Morsink
- Bas van Nimwegen
- Ilva van Houwelingen
Institutions
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Radboud University Medical Center (NL)
Publication Details
- Journal
- European Radiology Experimental
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1186/s41747-024-00511-8
- Citations
- 3
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- Universiteit Utrecht
- Technische Universiteit Delft
- Radboud Universiteit
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Radboud Universitair Medisch Centrum
- Stichting voor de Technische Wetenschappen