HMGCR as a promising molecular target for therapeutic intervention in aortic aneurisms: a mendelian randomization study
Our MR analysis offered compelling evidence of a plausible causal link between HMGCR and an increased risk of aortic aneurism, encompassing both thoracic and abdominal types. These groundbreaking findings further bolster the case for the deployment of HMGCR inhibitors in the treatment of aortic aneurisms, including both thoracic and abdominal variants.
Authors
- Jin He (ORCID: https://orcid.org/0000-0001-9698-1816)
- Zhaofen Zheng
- Peng‐Fei Zheng (ORCID: https://orcid.org/0000-0002-5826-5736)
- Peng Liu (ORCID: https://orcid.org/0000-0002-3095-0352)
- Jingjing Rong (ORCID: https://orcid.org/0000-0001-5269-3230)
Institutions
- Hunan Xiangdian Test Research Institute (China) (CN)
- Hunan Entry-Exit Inspection and Quarantine Bureau (CN)
- Hunan Provincial People's Hospital (CN)
Publication Details
- Journal
- Nutrition & Metabolism
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1186/s12986-024-00849-1
- Citations
- 3
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China