Impact of Age and Concurrent Antiseizure Medication Use on Lacosamide Dose to Concentration Ratio and Dosing in Pediatric Patients
The correlation between age and DCR was weak, accounting for 6% of variability. Strong inducers significantly increased DCR. Synergy may exist when multiple inducers are given. Weak inhibitors did not affect DCR. Those ≥6 to 11 kg, ≥30 to 50 kg, and those given strong inducers may require larger -initial LCM doses. Serum concentrations should be used to individualize dosing, especially in those receiving strong inducers.
Authors
- Stephanie J. Phelps
- James W. Wheless (ORCID: https://orcid.org/0000-0002-4735-3431)
- Bernd Meibohm (ORCID: https://orcid.org/0000-0003-3923-3648)
- Megan Woods
- Michael L. Christensen (ORCID: https://orcid.org/0000-0003-2649-6967)
Institutions
- University of Tennessee Health Science Center (US)
- Le Bonheur Children's Hospital (US)
Publication Details
- Journal
- The Journal of Pediatric Pharmacology and Therapeutics
- Published
- 2024-10-01
- DOI
- https://doi.org/10.5863/1551-6776-29.5.514
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer
- GlaxoSmithKline
- Sunovion
- Eisai
- H. Lundbeck A/S
- National Institutes of Health